Open Syndrome Zika
Table of Contents
Authors: PAHO
Location: Americas
Purpose #
The definition #
Patient with rash* with two or more of the following signs or symptoms:
fever, usually <38.5 ° C
conjunctivitis (non-purulent/hyperemic)
arthralgia
myalgia
peri-articular edema
*usually pruritic and maculopapular
Machine-readable definition #
The definition is available in JSON format following the Open Syndrome v1.0 specification:
{
"category": "suspected",
"definition_type": "case_definition",
"description": "",
"human_readable_definition": "Patient with rash* with two or more of the following signs or symptoms:\n\n fever, usually \u0026lt;38.5 ° C\n conjunctivitis (non-purulent/hyperemic)\n arthralgia\n myalgia\n peri-articular edema\n\n*usually pruritic and maculopapular",
"inclusion_criteria": [
{
"logical_operator": "AND",
"type": "criterion",
"values": [
{
"description": "Usually pruritic and maculopapular",
"name": "Rash",
"type": "symptom"
},
{
"logical_operator": "AT_LEAST",
"logical_operator_arguments": [
2
],
"type": "criterion",
"values": [
{
"attribute": "body_temperature",
"name": "Fever",
"operator": "\u003e=",
"type": "symptom",
"unit": "Celsius",
"value": 38.5
},
{
"name": "Conjunctivitis (non-purulent/hyperemic)",
"type": "symptom"
},
{
"name": "Arthralgia",
"type": "symptom"
},
{
"name": "Myalgia",
"type": "symptom"
},
{
"name": "Peri-articular edema",
"type": "symptom"
}
]
}
]
}
],
"keywords": [
"Zika virus"
],
"language": "English",
"location": "Americas",
"open_syndrome_version": "1.0.0",
"organization": "PAHO",
"published_at": "2025-02-08T18:05:28Z",
"published_by": [
"Open Syndrome Initiative"
],
"published_in": "https://opensyndrome.org",
"references": [
{
"url": "https://www.paho.org/en/topics/zika/zika-resources-case-definitions"
}
],
"scope": "broad",
"status": "draft",
"target_public_health_threats": [
"Zika virus"
],
"title": "Open Syndrome Zika",
"version": "1.0.0"
}
Using the Definition #
Healthcare organizations can implement this definition through:
- Direct integration with surveillance systems
- API endpoints for real-time validation
- Manual case verification processes
Next Steps #
We encourage:
- Clinical feedback on the definition criteria
- Technical feedback on the implementation format
- Suggestions for additional symptoms or signs
- Reports of implementation experiences
Get Involved #
We welcome contributions and feedback from the community.