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  1. Case Definitions/

Open Syndrome Lyme Disease

Authors: U.S. Centers for Disease Control and Prevention (CDC)

Location: United States

Purpose #

The definition #

Machine-readable definition #

The definition is available in JSON format following the Open Syndrome v1.0 specification:

{
   "category": "suspected",
   "definition_type": "case_definition",
   "description": "",
   "exclusion_criteria": [
     {
       "name": "History of lyme disease",
       "type": "epidemiological_history"
     }
   ],
   "human_readable_definition": "",
   "inclusion_criteria": [
     {
       "code": {
         "code": "A692",
         "system": "ICD-10"
       },
       "name": "Lyme disease",
       "type": "diagnosis"
     },
     {
       "logical_operator": "OR",
       "name": "Bull's eye rashes",
       "type": "criterion",
       "values": [
         {
           "logical_operator": "AND",
           "type": "criterion",
           "values": [
             {
               "name": "Bull's eye",
               "type": "symptom"
             },
             {
               "name": "Rash",
               "type": "symptom"
             }
           ]
         }
       ]
     }
   ],
   "keywords": [
     "Lyme disease"
   ],
   "language": "English",
   "location": "United States",
   "open_syndrome_version": "1.0.0",
   "organization": "U.S. Centers for Disease Control and Prevention (CDC)",
   "published_at": "2025-02-08T19:07:35Z",
   "published_by": [
     "Open Syndrome Initiative"
   ],
   "published_in": "https://opensyndrome.org",
   "references": [
     {
       "url": "https://knowledgerepository.syndromicsurveillance.org/lyme-disease-centers-disease-control-and-prevention"
     }
   ],
   "scope": "specific",
   "status": "draft",
   "target_public_health_threats": [
     "Lyme disease"
   ],
   "title": "Open Syndrome Lyme Disease",
   "version": "1.0.0"
 }

Using the Definition #

Healthcare organizations can implement this definition through:

  • Direct integration with surveillance systems
  • API endpoints for real-time validation
  • Manual case verification processes

Next Steps #

We encourage:

  • Clinical feedback on the definition criteria
  • Technical feedback on the implementation format
  • Suggestions for additional symptoms or signs
  • Reports of implementation experiences

Get Involved #

We welcome contributions and feedback from the community.