Open Syndrome Lujo Hemorrhagic Fever

{
   "category": "suspected",
   "definition_type": "case_definition",
   "description": "Case definition for suspected Lujo viral hemorrhagic fever",
   "human_readable_definition": "A person with acute onset of fever\n\u003e38.5°C, and at least three of the\nfollowing signs and symptoms:\n severe headache, myalgia,\n diarrhea,\n pharyngitis, abdominal pain,\nretrosternal chest pain,\nrespiratory distress,\n moderate thrombocytopenia,\n increased AST and\n leukocytosis,\n proteinuria,\n neurological signs or\n sudden inexplicable death\nAND a likely epidemiological exposure\nincluding any of\n contact with a suspected,\nprobable or confirmed Lujo case,\nor\n contact with a dead or sick\nanimal especially rodents within\nthe past 21 days.",
   "inclusion_criteria": [
     {
       "logical_operator": "AND",
       "type": "criterion",
       "values": [
         {
           "description": "\u003e38.5°C",
           "name": "fever",
           "type": "symptom"
         },
         {
           "logical_operator": "AT_LEAST",
           "logical_operator_arguments": [
             3
           ],
           "type": "criterion",
           "values": [
             {
               "name": "severe headache",
               "type": "symptom"
             },
             {
               "name": "myalgia",
               "type": "symptom"
             },
             {
               "name": "diarrhea",
               "type": "symptom"
             },
             {
               "name": "pharyngitis",
               "type": "symptom"
             },
             {
               "name": "abdominal pain",
               "type": "symptom"
             },
             {
               "name": "retrosternal chest pain",
               "type": "symptom"
             },
             {
               "name": "respiratory distress",
               "type": "symptom"
             },
             {
               "name": "moderate thrombocytopenia",
               "type": "symptom"
             },
             {
               "name": "increased AST",
               "type": "symptom"
             },
             {
               "name": "leukocytosis",
               "type": "symptom"
             },
             {
               "name": "proteinuria",
               "type": "symptom"
             },
             {
               "name": "neurological signs",
               "type": "symptom"
             },
             {
               "name": "sudden inexplicable death",
               "type": "symptom"
             }
           ]
         },
         {
           "logical_operator": "AT_LEAST",
           "logical_operator_arguments": [
             1
           ],
           "type": "criterion",
           "values": [
             {
               "description": "Contact with a suspected, probable or confirmed Lujo case within past 21 days",
               "name": "contact with Lujo case",
               "type": "epidemiological_history"
             },
             {
               "description": "Contact with a dead or sick animal especially rodents within past 21 days",
               "name": "contact with animal",
               "type": "epidemiological_history"
             }
           ]
         }
       ]
     }
   ],
   "keywords": [
     "Lujo hemorrhagic fever",
     "Africa"
   ],
   "language": "English",
   "location": "South Africa",
   "open_syndrome_version": "1.0.0",
   "organization": "National Institute for Communicable Diseases (NICD)",
   "published_at": "2025-01-29T12:00:00Z",
   "published_by": [
     "Open Syndrome Initiative"
   ],
   "published_in": "https://opensyndrome.org",
   "references": [
     {
       "url": "https://www.nicd.ac.za/wp-content/uploads/2021/08/VIRAL-HAEMORRHAGIC-FEVER-DISEASES_Lujo-case-definition.pdf"
     }
   ],
   "scope": "specific",
   "status": "draft",
   "target_public_health_threats": [
     "Lujo hemorrhagic fever"
   ],
   "title": "Open Syndrome Lujo Hemorrhagic Fever",
   "version": "1.0.0"
 }