Open Syndrome Leptospirosis
Table of Contents
Authors: Robert Koch Institute
Location: Germany
Purpose #
Case definition for suspected leptospirosis in Germany
The definition #
Klinisches Bild einer akuten Leptospirose, definiert als mindestens eines der neun folgenden Kriterien:
- ►allgemeine Krankheitszeichen,
- Dyspnoe (Atemstörung),
- ►Fieber,
- Hämorrhagien (z.B. Lungenblutungen, subkonjunktivale Blutungen),
- Husten,
- Ikterus (Gelbsucht),
- Meningitis oder Meningoenzephalitis,
- Myokarditis (Herzmuskelentzündung),
- ►Nierenfunktionsstörung ODER ►krankheitsbedingter Tod.
Machine-readable definition #
The definition is available in JSON format following the Open Syndrome v1.0 specification:
{
"category": "suspected",
"definition_type": "case_definition",
"description": "Case definition for suspected leptospirosis in Germany",
"human_readable_definition": "Klinisches Bild einer akuten Leptospirose, definiert als mindestens eines der neun folgenden Kriterien:\n- ►allgemeine Krankheitszeichen,\n- Dyspnoe (Atemstörung),\n- ►Fieber,\n- Hämorrhagien (z.B. Lungenblutungen, subkonjunktivale Blutungen),\n- Husten,\n- Ikterus (Gelbsucht),\n- Meningitis oder Meningoenzephalitis,\n- Myokarditis (Herzmuskelentzündung),\n- ►Nierenfunktionsstörung\nODER ►krankheitsbedingter Tod.",
"inclusion_criteria": [
{
"logical_operator": "OR",
"type": "criterion",
"values": [
{
"name": "General symptoms",
"type": "symptom"
},
{
"name": "Dyspnea (respiratory distress)",
"type": "symptom"
},
{
"name": "Fever",
"type": "symptom"
},
{
"name": "Hemorrhagia (e.g., pulmonary hemorrhage, subconjunctival hemorrhage)",
"type": "symptom"
},
{
"name": "Cough",
"type": "symptom"
},
{
"name": "Icterus (jaundice)",
"type": "symptom"
},
{
"name": "Meningitis or meningoencephalitis",
"type": "professional_judgment"
},
{
"name": "Myocarditis (myocardial inflammation)",
"type": "symptom"
},
{
"name": "Renal function disorder",
"type": "symptom"
},
{
"name": "Death due to disease",
"type": "professional_judgment"
}
]
}
],
"keywords": [
"Leptospirosis",
"Europe"
],
"language": "English",
"location": "Germany",
"open_syndrome_version": "1.0.0",
"organization": "Robert Koch Institute",
"published_at": "2025-02-08T09:13:10Z",
"published_by": [
"Open Syndrome Initiative"
],
"published_in": "https://opensyndrome.org",
"references": [
{
"citation": "",
"url": "https://www.rki.de/DE/Content/Infekt/IfSG/Falldefinition/Downloads/Falldefinitionen_des_RKI_2023.pdf?__blob=publicationFile"
}
],
"scope": "specific",
"status": "draft",
"target_public_health_threats": [
"Leptospirosis"
],
"title": "Open Syndrome Leptospirosis",
"version": "1.0.0"
}
Using the Definition #
Healthcare organizations can implement this definition through:
- Direct integration with surveillance systems
- API endpoints for real-time validation
- Manual case verification processes
Next Steps #
We encourage:
- Clinical feedback on the definition criteria
- Technical feedback on the implementation format
- Suggestions for additional symptoms or signs
- Reports of implementation experiences
Get Involved #
We welcome contributions and feedback from the community.