Skip to main content
  1. Case Definitions/

Open Syndrome Influenza-like Illness (ILI)

Authors: Ministry of Health

Location: Brazil

Purpose #

Standardized case definition of suspected influenza-like illness for adults

The definition #

Indivíduo que apresente febre de início súbito, mesmo que referida, acompanhada de tosse ou dor de garganta e pelo menos um dos seguin- tes sintomas: cefaleia, mialgia ou artralgia, na ausência de outro diagnós- tico específico.

Machine-readable definition #

The definition is available in JSON format following the Open Syndrome v1.0 specification:

{
   "category": "suspected",
   "definition_type": "case_definition",
   "description": "Standardized case definition of suspected influenza-like illness for adults",
   "exclusion_criteria": [
     {
       "description": "Presence of any other specific diagnosis that explains the symptoms",
       "name": "Other specific diagnosis",
       "type": "diagnosis"
     }
   ],
   "human_readable_definition": "Indivíduo que apresente febre de início súbito, mesmo que referida,\nacompanhada de tosse ou dor de garganta e pelo menos um dos seguin-\ntes sintomas: cefaleia, mialgia ou artralgia, na ausência de outro diagnós-\ntico específico.",
   "inclusion_criteria": [
     {
       "logical_operator": "AND",
       "type": "criterion",
       "values": [
         {
           "description": "Sudden onset fever, even if self-reported",
           "name": "Fever",
           "type": "symptom"
         },
         {
           "logical_operator": "OR",
           "type": "criterion",
           "values": [
             {
               "name": "Cough",
               "type": "symptom"
             },
             {
               "name": "Sore throat",
               "type": "symptom"
             }
           ]
         },
         {
           "logical_operator": "AT_LEAST",
           "logical_operator_arguments": [
             1
           ],
           "type": "criterion",
           "values": [
             {
               "name": "Headache",
               "type": "symptom"
             },
             {
               "name": "Myalgia",
               "type": "symptom"
             },
             {
               "name": "Arthralgia",
               "type": "symptom"
             }
           ]
         }
       ]
     }
   ],
   "keywords": [
     "Influenza-like Illness (ILI)",
     "South America"
   ],
   "language": "English",
   "location": "Brazil",
   "open_syndrome_version": "1.0.0",
   "organization": "Ministry of Health",
   "published_at": "2025-01-29T12:00:00Z",
   "published_by": [
     "Open Syndrome Initiative"
   ],
   "published_in": "https://opensyndrome.org/case-definitions",
   "references": [
     {
       "url": "https://www.gov.br/ebserh/pt-br/hospitais-universitarios/regiao-sudeste/hc-ufu/saude/epidemiologia/protocolos/protocolo/protocolo-de-sindrome-gripal-e-sindrome-respiratoria-aguda-grave-com-enfase-em-influenza"
     }
   ],
   "scope": "specific",
   "status": "draft",
   "target_public_health_threats": [
     "Influenza-like Illness (ILI)"
   ],
   "title": "Open Syndrome Influenza-like Illness (ILI)",
   "version": "1.0.0"
 }

Using the Definition #

Healthcare organizations can implement this definition through:

  • Direct integration with surveillance systems
  • API endpoints for real-time validation
  • Manual case verification processes

Next Steps #

We encourage:

  • Clinical feedback on the definition criteria
  • Technical feedback on the implementation format
  • Suggestions for additional symptoms or signs
  • Reports of implementation experiences

Get Involved #

We welcome contributions and feedback from the community.