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  1. Case Definitions/

Open Syndrome Hepatitis A

Authors: Turkish Ministry of Health’s General Directorate of Public Health

Location: Turkey

Purpose #

Viral hepatitis

The definition #

The presence of the following two clinical criteria.

  1. Sudden onset of abdominal pain, loss of appetite, fatigue, nausea, vomiting in an individual
  2. Presence of at least one of the following clinical criteria: • Fever • Jaundice • Elevated serum aminotransferases (ALT and AST) and increased levels of urobilinogen in urine (NOTE: It should be remembered that it may often be asymptomatic and/or anicteric.)

Machine-readable definition #

The definition is available in JSON format following the Open Syndrome v1.0 specification:

{
   "category": "suspected",
   "definition_type": "case_definition",
   "description": "Viral hepatitis",
   "human_readable_definition": "The presence of the following two clinical criteria.\n1. Sudden onset of abdominal pain, loss of appetite, fatigue, nausea, vomiting in an individual\n2. Presence of at least one of the following clinical criteria:\n• Fever\n• Jaundice\n• Elevated serum aminotransferases (ALT and AST) and increased levels of urobilinogen in urine\n(NOTE: It should be remembered that it may often be asymptomatic and/or anicteric.)",
   "inclusion_criteria": [
     {
       "logical_operator": "AND",
       "type": "criterion",
       "values": [
         {
           "logical_operator": "AND",
           "type": "criterion",
           "values": [
             {
               "name": "Sudden onset of abdominal pain, loss of appetite, weakness, nausea, vomiting",
               "type": "symptom"
             },
             {
               "logical_operator": "AT_LEAST",
               "logical_operator_arguments": [
                 1
               ],
               "name": "At least one of the following clinical criteria",
               "type": "criterion",
               "values": [
                 {
                   "name": "Fever",
                   "type": "symptom"
                 },
                 {
                   "name": "Jaundice",
                   "type": "symptom"
                 },
                 {
                   "name": "Increased serum aminotransferase (ALT and AST), urobilinogen in urine",
                   "type": "symptom"
                 }
               ]
             }
           ]
         }
       ]
     }
   ],
   "keywords": [
     "Hepatitis A",
     "Asia"
   ],
   "language": "English",
   "location": "Turkey",
   "notes": [
     "It should be remembered that it may be mostly asymptomatic and/or anicteric"
   ],
   "open_syndrome_version": "1.0.0",
   "organization": "Turkish Ministry of Health's General Directorate of Public Health",
   "published_at": "2025-01-29T12:00:00Z",
   "published_by": [
     "Open Syndrome Initiative"
   ],
   "published_in": "https://opensyndrome.org",
   "references": [
     {
       "type": "web",
       "url": "https://hsgm.saglik.gov.tr/depo/birimler/bulasici-hastaliklar-ve-erken-uyari-db/Dokumanlar/Sunumlar/TVHKP_Viral_Hepatitlerin_Bildirimi.pdf"
     }
   ],
   "scope": "broad",
   "status": "draft",
   "target_public_health_threats": [
     "Hepatitis A"
   ],
   "title": "Open Syndrome Hepatitis A",
   "version": "1.0.0"
 }

Using the Definition #

Healthcare organizations can implement this definition through:

  • Direct integration with surveillance systems
  • API endpoints for real-time validation
  • Manual case verification processes

Next Steps #

We encourage:

  • Clinical feedback on the definition criteria
  • Technical feedback on the implementation format
  • Suggestions for additional symptoms or signs
  • Reports of implementation experiences

Get Involved #

We welcome contributions and feedback from the community.